Anthelmintics: Discovery to Resistance III by Kyle Lesack

A few weeks ago, I was fortunate to attend the Anthelmintics III conference in Indian Rocks Beach, Florida. This opportunity allowed me to learn more about cutting edge research in a variety of topics related to the development of anthelmintic drugs, including drug discovery, anthelmintic resistance mechanisms, and future parasite control strategies. The conference included a diverse group of speakers from both academia and industry, and their talks provided excellent insight into some of the challenges that I will be facing in my PhD thesis work on detoxification gene families in nematodes. Some of my favorite talks included Dave Curran’s demonstration on the use of metabolic networks to study the relationship between Wolbachia and filarial nematodes, the genetic basis of benzimidazole resistance in C. elegans by Steffan Hahnel, and an analysis of thiabendazole-induced expression of seven cytochrome P450 genes in H. contortus by Jürgen Krücken.

I had the opportunity to present our work on an evolutionary analysis of drug metabolising pathways from several members of the Caenorhabditis genus. I received excellent feedback from experts in the field, which will help me going forward. I was also pleased that several researchers expressed interest in using our bioinformatics tools (developed by Dr. Dave Curran while he was a member of the Wasmuth lab) for their own research.

I would like to thank the HPI group and my supervisor Dr. James Wasmuth for this opportunity. I hope that I will have the opportunity to attend the Anthelmintics IV conference in 2020!

Picture1.pngExample of the local fauna

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